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抗疫尚未成功 大家仍須努力

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<div class="pasteContent" style="display:inline;" _ngcontent-c40=""> <p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family:&quot;新細明體&quot;,serif;"><span style="font-size: 12pt;"><br></span></span></p><p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">前幾天一篇新的研究被發表在「細胞」(</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">Cell</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">)期刊中,這篇研究發現令人震驚</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">:</span></span><br> </span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">新冠病毒讓世界陷入封鎖,但仍然</span></span><span style="font-family:&quot;新細明體&quot;,serif;"><span style="font-size: 12pt;"><strong>藉由突變增加傳染力</strong>! </span></span></p> <br> <p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">Cell (</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">細胞期刊</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">) </span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">主要是發表醫學及生命科學領域中的最新研究發現。</span></span></p> <p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">細胞期刊刊登過許多重大的生物科學研究進展的文章,與</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">Nature </span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">自然期刊</span></span> <span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">和</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">Science</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">科學期刊並列為全世界三大最權威的學術雜誌之一。</span></span></p> <br> <p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">Cell</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">期刊的新研究指出正在全球流行的新型冠狀病毒出現基因變異,比起在武漢華南市場發現的病毒株更容易感染人類細胞。</span></span></p> <br> <p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">新型冠狀病毒是某一類</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">RNA</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">病毒的總稱,就如同其他冠狀病毒一樣,</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">SARS-CoV-2</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">在其外套膜上有突出像棒狀的棘蛋白(</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">spike</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">,</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">S protein</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">)環繞在它的核心外。</span></span> </p> <p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">就是透過棘蛋白會與人體上的血管收縮素轉化酶</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">2</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">(</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">Angiotensin converting enzyme2, ACE2</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">)互相結合的機制,來感染人的呼吸道上皮細胞而致病。</span></span></p> </div><p><br></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><p><br></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><img class="e-rte-image e-imginline" width="auto" height="auto" alt="圖片1@.png" src="https://expert.med-net.com/upload/ArticleDetail/222/圖片1@.png" style="min-width: 0px; min-height: 0px;"></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><br></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><br></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""> <p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">期刊指出在新冠病毒外套膜上的棘蛋白第</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">614</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">個胺基酸透過突變從“</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">D” (aspartic acid </span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">天門冬胺酸</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">) </span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">轉變成“</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">G” (glycine </span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">甘氨酸</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">)</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">,科學家發現就僅僅是一個胺基酸的改變,就會影響三個相同的氨基酸鏈,可能會使棘蛋白在傳染的過程中變得更有效率,從而增強病毒的傳染性</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">; </span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">目前沒有證據顯示這樣的突變會使受感染者病情更嚴重或是死亡率增加,但是確實發現有</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">D614G</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">突變的受感染者,血液中病毒量比沒有突變的病毒數量更多,更容易傳染給別人。</span></span></p> </div><br></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><p><br></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""></div></div><br></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""> <p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family:&quot;新細明體&quot;,serif;"><span style="font-size: 12pt;"><img class="e-rte-image e-imginline" width="auto" height="auto" alt="圖片84.png" src="https://expert.med-net.com/upload/ArticleDetail/222/圖片84.png" style="min-width: 0px; min-height: 0px;"><br></span></span></p><p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family:&quot;新細明體&quot;,serif;"><span style="font-size: 12pt;"><br></span></span></p><p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family:&quot;新細明體&quot;,serif;"><span style="font-size: 12pt;"><br></span></span></p><p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family:&quot;新細明體&quot;,serif;"><span style="font-size: 12pt;"><br></span></span></p><p style="font-family:&quot;Calibri&quot;,sans-serif;margin:0cm;margin-bottom:.0001pt;"><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">雖然目前台灣相較於其他國家疫情穩定,但是新冠病毒透過進化不斷的進化來增強感染力,當全世界每天增加</span></span><span lang="EN-US"><span style="font-size: 12pt;"><span style="font-family: &quot;Segoe UI&quot;;">10</span></span></span><span style="font-family: &quot;Segoe UI&quot;;"><span style="font-size: 12pt;">萬病例時,表示疫情還沒有趨緩,在解封後、疫苗出來之前最好還是</span><span style="font-size: 12pt;"><strong><span style="color: rgb(255, 0, 0); text-decoration: inherit;">保持社交距離、出入公共場所配戴口罩以及勤洗手</span></strong></span><span style="font-size: 12pt;">。</span></span></p> <br></div><br></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><img class="e-rte-image e-imginline" width="auto" height="auto" alt="84.jpg" src="https://expert.med-net.com/upload/ArticleDetail/222/84.jpg" style="min-width: 0px; min-height: 0px;"><br></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><br><br><div class="pasteContent" style="display:inline;" _ngcontent-c11=""><span style=" background-color: rgb(255, 255, 255);color: rgb(136, 136, 136); display: inline !important; float: none; font-family: Lato, sans-serif; font-size: 15px; font-weight: 400; text-align: start; text-indent: 0px; white-space: normal;"><br></span></div></div></div><div><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c11=""><span style=" background-color: rgb(255, 255, 255);color: rgb(136, 136, 136); display: inline !important; float: none; font-family: Lato, sans-serif; font-size: 15px; font-weight: 400; text-align: start; text-indent: 0px; white-space: normal;"><br></span></div></div></div></div><div><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c11=""><span style=" background-color: rgb(255, 255, 255);color: rgb(136, 136, 136); display: inline !important; float: none; font-family: Lato, sans-serif; font-size: 15px; font-weight: 400; text-align: start; text-indent: 0px; white-space: normal;"><br></span></div></div></div></div><div><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c11=""><span style="color: rgb(0, 0, 0); text-decoration: inherit;"><strong><span style="font-family: &quot;Segoe UI&quot;;">參考文獻: </span></strong></span><span style="color: rgb(0, 0, 0); text-decoration: inherit;"><strong><span style="font-family: &quot;Segoe UI&quot;;">Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus</span></strong></span><!--EndFragment--> </div><br></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><br></div></div><p></p><p></p><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""><div class="pasteContent" style="display:inline;" _ngcontent-c40=""> <!--StartFragment--><span style=" background-color: rgb(245, 245, 245); color: rgb(0, 0, 0); display: inline; font-family: &quot;Noto Sans TC&quot;, sans-serif; font-size: 13.33px; font-style: normal; line-height: inherit; max-width: 100%; padding: 0px; text-align: left; text-indent: 0px; vertical-align: baseline; white-space: normal;">◎撰文/台北醫學大學附設醫院肝膽腸胃科主治醫師方冠傑</span><span style=" background-color: rgb(255, 255, 255); color: rgb(51, 51, 51); display: inline; font-family: &quot;Noto Sans TC&quot;, sans-serif; font-size: 14px; font-style: normal; line-height: inherit; max-width: 100%; padding: 0px; text-align: left; text-indent: 0px; vertical-align: baseline; white-space: normal;"><span style=" border: 0px; font-family: inherit; font-size: 14px; font-style: inherit; line-height: inherit; max-width: 100%; padding: 0px; vertical-align: baseline;">&nbsp;</span></span><!--EndFragment--> </div><br></div></div><p></p></div>

方冠傑

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2020:07:06

醫學新知


            
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